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KMID : 0816119980010010090
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Korean Journal of Pediatric Gastroenterolology and Nutrition
1998 Volume.1 No. 1 p.90 ~ p.99
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A Study of Serum Cytokines in the Patients with Chronic Hepatitis B Virus Infection
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Kim Byung-Ju
Hwang Tai-Ju
Ma Jae-Sook
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Abstract
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Purpose: The aim of this study was to clarify the serum cytokine pattern in patients
with chronic HBV infection in terms of their clinical state.
Methods: Intravenous blood samples were taken from 35 patients who were
seropositive for HBsAg for at least 6 months and 7 healthy controls. Samples were
initially tested for serum aminotransferases and serologic markers for hepatitis B virus
by EIA. Serum levels of interleukin(IL)-2, tumor necrosis factor-alpha (TNF-α),
interferon-gamma (IFN-γ), IL-4, and IL-10 were measured by ELISA.
Results: Among 35 patients, seropositive for HBeAg was 20 and for anti-HBe was 15.
The histologic diagnosis of 19 patients underwent liver biopsy were chronic persistent
hepatitis (CPH) in 10 and chronic active hepatitis (CAH) in 9. Serum IL-10 level in
patients seropositive for HBeAg was significantly higher than that in patients
seropositive for anti-HBe (p<0.05). All measured cytokine levels in patients with CAH
were higher than those of patients with CPH. High values of all measured cytokines
except IL-4 were seen in patients with AST and ALT > 100 U/L. High level of IL-4
was seen in patients with normal aminotransferase levels.
Conclusion: These results were thought to indicate that anti-inflammatory Th2-like
cytokine (IL-10) production in chronic HBV infection is related to circulating HBeAg
rather than activity of hepatitis and that Th1 cytokines seem to be associated with the
increasing activity of hepatitis.
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KEYWORD
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Serum cytokine, Chronic hepatitis B infection,
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